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Keto and Inflammation: Markers Worth Watching

23 October 2026 · Keto Side Effects · 4 min read

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The ketogenic diet, characterised by its low carbohydrate and high fat composition, has gained popularity for its potential health benefits. One area of interest is its impact on inflammation. While some studies suggest keto can reduce inflammation, the relationship is complex and depends on various factors. It’s important to understand which inflammation markers to monitor when following a ketogenic diet.

Understanding Inflammation

Inflammation is the body’s natural response to injury or infection. It’s a complex process involving various immune cells and molecules. Chronic inflammation, however, is linked to several health issues, including heart disease, type 2 diabetes, and arthritis. Diet plays a significant role in modulating inflammation. Certain foods can promote inflammation, while others may have anti-inflammatory effects. The ketogenic diet’s impact on inflammation appears to be mixed, with potential benefits and risks depending on individual factors and how well the diet is managed. keto flu symptoms can sometimes be mistaken for an inflammatory response.

Key Inflammation Markers to Monitor

Several markers can indicate the level of inflammation in the body. C-reactive protein (CRP) is a common marker measured in blood tests. High-sensitivity CRP (hs-CRP) is even more sensitive and can detect subtle changes in inflammation. Interleukin-6 (IL-6) and tumour necrosis factor-alpha (TNF-α) are other inflammatory cytokines that can be measured. On a ketogenic diet, monitoring these markers can provide insights into how the diet is affecting your inflammatory status. It’s best to work with your GP to test and interpret these markers, rather than self-diagnosing.

Potential Anti-Inflammatory Effects of Keto

The ketogenic diet may reduce inflammation through several mechanisms. Ketones, produced during ketosis, have been shown to have anti-inflammatory properties. One ketone body, beta-hydroxybutyrate (BHB), can inhibit certain inflammatory pathways. Additionally, the reduction in carbohydrate intake on a ketogenic diet can lower blood sugar levels and insulin resistance, which are often associated with inflammation. keto for insulin resistance may be worth investigating if your doctor agrees. A study showed that carbohydrate restriction improves metabolic syndrome independent of weight loss, suggesting a direct anti-inflammatory effect beyond weight reduction.

Factors Influencing Inflammation on Keto

While keto may have anti-inflammatory potential, certain factors can influence its effects. The type of fats consumed on a ketogenic diet matters. A diet high in processed fats may promote inflammation, while one rich in omega-3 fatty acids may have anti-inflammatory benefits. Nutrient deficiencies can also contribute to inflammation. Ensuring adequate intake of vitamins and minerals is crucial. Individual responses to the ketogenic diet vary, and some people may experience increased inflammation, particularly if they have underlying health conditions.

What this means in practice

If you’re following a ketogenic diet, it’s wise to focus on whole, unprocessed foods. Choose healthy fats like avocados, olive oil, and fatty fish. Limit processed meats and refined oils. Consider supplementing with omega-3 fatty acids if you don’t consume enough through diet alone. A tub of avocados from Tesco costs around £4 and is a great source of healthy fats. Work with a healthcare professional to monitor your inflammation markers and adjust your diet as needed. If you feel unwell, don’t assume it’s just keto flu.

Frequently Asked Questions

Can keto cause inflammation?

While keto has the potential to reduce inflammation, it can also contribute to it in some cases. Factors like the type of fats consumed and individual responses play a role. Monitoring inflammation markers and working with a healthcare professional can help determine the diet’s impact on your body.

What foods should I avoid on keto to reduce inflammation?

Avoid processed foods, refined oils, and excessive amounts of saturated fats. Limit your intake of foods high in omega-6 fatty acids, such as vegetable oils. Focus on whole, unprocessed foods and healthy fats like avocados, olive oil, and fatty fish.

How long does it take to see anti-inflammatory effects on keto?

The time it takes to see anti-inflammatory effects on keto varies. Some people may experience improvements within a few weeks, while others may take longer. Consistency with the diet and lifestyle factors, such as stress management and sleep, can influence the results.

What are the best fats to eat on keto for reducing inflammation?

The best fats to eat on keto for reducing inflammation are those rich in omega-3 fatty acids, such as fatty fish (salmon, mackerel, sardines), flaxseeds, and chia seeds. Olive oil and avocado oil are also good choices. Limit your intake of processed fats and refined oils.

The Bottom Line

The ketogenic diet can influence inflammation, but the effects are complex and depend on various factors. Monitoring inflammation markers and focusing on a well-formulated diet rich in whole foods and healthy fats is crucial. Individual responses vary, and working with a healthcare professional can help optimise your results. If you’d rather not do the macro maths yourself, the Keto Dieting app does it for you on Google Play and the App Store.

Educational only — not medical advice. This article is for general information. Speak to your GP before changing your diet, especially if you have type 1 or type 2 diabetes, kidney or liver disease, are pregnant or breastfeeding, or take medication for blood pressure, cholesterol, or blood glucose.

References

  1. Hyde PN, Sapper TN, Crabtree CD, et al. (2019). Dietary carbohydrate restriction improves metabolic syndrome independent of weight loss. JCI Insight. https://doi.org/10.1172/jci.insight.128308

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